Advances in Therapy, an international medical journal, has published the Research Article “Familial Hypercholesterolemia identification algorithm in patients with acute cardiovascular event in a large hospital electronic database in Bulgaria – a call for implementation”

Sqilline is extremely honored to be a co-writer among such extreme professionals and experts in the field.

Our advanced solution Danny Platform® played a key role in the process and analysis of this fundamental article.

Click to play the abstract video of the article:

KEY SUMMARY POINTS:

OBJECTIVES:

• Using all available medical records from EHR systems to extract treated patients admitted for ASCVD acute events to screen for FH
• Reinforce early FH identification and improving patient pathways and outcomes

CHALLENGES:

• Limited data on the proportion and management of FH among adults
• Under diagnosed, an acute event is usually the 1st clinical manifestation of FH
• Most patients are unaware they have it until a significant cardio event occurs

SOLUTION:

• Danny Platform’s NLP algorithm was developed to identify patients with arcus Cornealis, tendon xanthoma, or stated FH
• Danny Platform’s algorithms search the EHR of patients admitted to hospital for the treatment of an acute CV event to identify those with undiagnosed FH
• The platform can automatically calculate the Dutch Lipid Clinic Network Score(DLCNS)

RESULTS:

• 11 090 patients recorded an acute cardiovascular event
• 44% of patients have possible FH and 56% have probable/definite FH
• 37% of patients discharged with high-intensity statin therapy
• 96% of patients had poorly controlled cholesterol during the first year after discharge

BENEFITS:

• Systematic screening and early identification of FH during hospitalization will improve patients’ treatment and outcomes
• Empowering physicians to reinforcing early FH identification to improve future patient outcomes
• Reducing burden on the healthcare system via automated screening tool during hospitalization may allow for rapid and effective lipid management, prevention of recurrent events

ARTICLE AUTHORS:

• Prof. Ivo Petrov (Head of Cardiology, Angiology and Electrophysiology Department: Acibadem City Clinic Cardiovascular Center)
• Assos. Prof. Arman Postadzhiyan (Department of General Medicine, Emergency University Hospital “St. Anna”, Medical University of Sofia)
• Dr. Dobrin Vasilev (Head Cardiology Clinic at Alexandrovska University Hospital)
• Dr. Ruslan Kasabov (Department of Interventional Cardiology: Hospital “Pulmed” Plovdiv
• Prof. Dr. Fedya Nikolov and Assos. Prof. Mariya Tokmakova (Department of Cardiology, Medical University of Plovdiv)
• Reneta Petkova (Department of General Medicine, Amgen Bulgaria)
• Veselin Istatkov, Boyang Zhao, and Dimiter Mutafchiev (Sqilline)

Click here to read the full publication in Advances in Therapy